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KMID : 0362220130400020095
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Journal of The Korean Research Society for Dental Materials
2013 Volume.40 No. 2 p.95 ~ p.102
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Cytotoxicity of gutta-percha points and thermoplastic endodontic obturation materials
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Kim Jung-Hwan
Song Yo-Han
Kim Ji-Woo
Lee Eung-Beom
Song Ho-June
Park Young-Jun
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Abstract
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This study was purposed to evaluate the cytotoxicity of commercially available 3 types of prefabricated gutta-percha points and 8 types of thermoplastic endodontic obturation materials using MTT tests and agar overlay test.
On MTT test, the Obtura® showed significantly lower cell viability (16.3±0.8% vs. Control; p＜0.05), which is over four times lower than those of other tested materials (p＜0.05). The Diadent point®, Sure-endo point®, and Diadent Medium® showed rather higher cell viability compared to that of Control (p＜0.05).
On agar overlay test, Sure-endo Soft® and Sure-endo Hard® showed a lower cytotoxicity (decolorization index = 2) compared to other tested materials (decolorization index = 3), while all the tested materials ranked as ‘moderate cytotoxic’ (response index = 2/2 or 3/2).
From this study it is demonstrated that the endodontic obturation materials have various degrees of cytotoxicity, and further in vivo biocompatibility evaluation is needed.
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KEYWORD
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Gutta-percha, thermoplastic materials, cytotoxicity, MTT, Agar overlay
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